Disruptions in effort-based decision-making and consummatory behavior following antagonism of the dopamine D2 receptor

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• 作者：Cindee F. Robles ; Alexander W. Johnson ; ^awj@msu.edu
• 关键词：Effort discounting ; Incentive ; Hedonic ; Mesocorticolimbic ; Mesostriatal
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：320
• 期：Complete
• 页码：431-439
• 全文大小：1517 K
• 卷排序：320

文摘

Dopamine is known to influence motivational processes. Disruptions in dopamine D2 receptor signaling on reward-based decision-making and consummatory behavior were studied. In mice, central infusion of D2 antagonist eticlopride impaired effort-based decision-making. Eticopride also attenuated sucrose consumption by reducing motivation to consume. Results suggest eticlopride reduced the willingness to engage in effortful operant responding and consumption of sucrose.