HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development
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- 作者：Changwang Deng1 ; Ying Li1 ; Lei Zhou2 ; 6 ; 7 ; Joonseok Cho3 ; Bhavita Patel1 ; Naohiro Terada3 ; Yangqiu Li4 ; Jö ; rg Bungert1 ; 6 ; 7 ; Yi Qiu5 ; 6 ; 7 ; qiuy@ufl.edu" class="auth_mail" title="E-mail the corresponding author ; Suming Huang1 ; 6 ; 7 ; sumingh@ufl.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HoxBlinc lincRNA ; SETD1A and MLL1 HMTs ; hoxb gene activation ; chromatin looping ; mesoderm specification
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：14
- 期：1
- 页码：103-114
- 全文大小：3621 K
文摘
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HoxBlinc RNA is required for mesoderm specification and hoxb gene activation
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HoxBlinc RNA specifies Flk1+ mesoderm toward cardiac/hematopoietic lineages
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HoxBlinc activates the Notch signaling and hematopoietic transcription networks
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Recruitment of Set1/MLL by HoxBlinc controls chromatin dynamics and hoxb expression