Subdivision of the lateral plate mesoderm and specification of the forelimb and hindlimb forming domains

详细信息    查看全文

• 作者：Satoko Nishimoto ; ^{satoko.nishimoto@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Malcolm P.O. Logan ; ^{malcolm.logan@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Lateral plate mesoderm ; Regionalization ; Limb development ; Tbx genes ; Hox genes ; Pitx1
• 刊名：Seminars in Cell & Developmental Biology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：49
• 期：Complete
• 页码：102-108
• 全文大小：871 K

文摘

The limbs are a significant evolutionary innovation that enabled vertebrates to diversify and colonise new environments. Tetrapods have two pairs of limbs, forelimbs in the upper body and hindlimbs in the lower body. The morphologies of the forelimbs and hindlimbs are distinct, reflecting their specific locomotory functions although they share many common signalling networks that regulate their development. The paired appendages in vertebrates form at fixed positions along the rostral–caudal axis and this occurs as a consequence of earlier subdivision of the lateral plate mesoderm (LPM) into regions with distinct limb forming potential. In this review, we discuss the molecular mechanisms that confer a broad region of the flank with limb-forming potential and its subsequent refinement into distinct forelimb-forming, hindlimb-forming and interlimb territories.