Development of Bipotent Cardiac/Skeletal Myogenic Progenitors from MESP1+ Mesoderm
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- 作者：Sunny Sun-Kin Chan1 ; 2 ; Hannah R. Hagen1 ; Scott A. Swanson3 ; Ron Stewart3 ; Karly A. Boll1 ; Joy Aho4 ; James A. Thomson3 ; Michael Kyba2 ; 5 ; kyba@umn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mesp1 ; mesoderm ; cardiopharyngeal mesoderm ; cardiac development ; skeletal myogenesis
- 刊名：Stem Cell Reports
- 出版年：2016
- 出版时间：12 January 2016
- 年：2016
- 卷：6
- 期：1
- 页码：26-34
- 全文大小：2321 K
文摘
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MESP1 induces bipotent PDGFRA+ cardiac/skeletal myogenic progenitors
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MESP1+ PDGFRA+ cells functionally resemble cardiopharyngeal mesoderm (CPM)
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TGFβ-BMP and Rho kinase signaling regulate CPM lineage choice
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PODXL and CDH4 mark early cardiac and skeletal myogenic-committed progenitors