Chemical modifications in the seed region of miRNAs 221/222 increase the silencing performances in gastrointestinal stromal tumor cells
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- 作者：Montano Dursoa ; 1 ; Maria Gaglioneb ; 1 ; Linda Pirasc ; 1 ; Maria Emilia Mercuriob ; Sara Terreria ; Michele Olivieria ; Luciana Marinellid ; Ettore Novellinod ; Mariarosaria Incoronatoe ; Paolo Griecod ; Gaetano Orsinif ; Giancarlo Tononf ; Anna Messereb ; 2 ; anna.messere@unina2.it" class="auth_mail" title="E-mail the corresponding author ; Amelia Cimminoa ; 2 ; cimmino@igb.cnr.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：miRNA mimics ; Chemically modified miR221/222 ; Therapeutic miRNAs ; GIST treatment ; Inhibitors of KIT gene expression
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：23 March 2016
- 年：2016
- 卷：111
- 期：Complete
- 页码：15-25
- 全文大小：1925 K
文摘
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New miRNA mimics with modified guide strands are reported.
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All miRNA mimics resulted effective inhibitors of KIT gene expression.
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Migration, cell proliferation, and apoptosis assays were performed on GIST 48 cell line.
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Modified miRNAs 221/222 may provide an alternative therapeutic option for GIST treatment.