The LC-MS-based metabolomics of hydroxytyrosol administration in rats reveals amelioration of the metabolic syndrome

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• 作者：Nikolaos Lemonakis^a ; Hemant Poudyal^b ; ^c ; Maria Halabalaki^a ; Lindsay Brown^b ; Anthony Tsarbopoulos^d ; Alexios-Leandros Skaltsounis^a ; Evagelos Gikas^e ; ^{vgikas@pharm.uoa.gr}
• 关键词：Hydroxytyrosol ; Metabolomics ; Metabolic pathway analysis ; Metabolic syndrome
• 刊名：Journal of Chromatography B
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：1041-1042
• 期：Complete
• 页码：45-59
• 全文大小：3401 K
• 卷排序：1041

文摘

A dual LC–MS (orbitrap and qQTof) metabolomics methodology has been developed for assessing the plasma rat metabolome of a metabolic syndrome model. The metabolomics methodology has been fully validated using multivariate analysis. Chronic administration of HT has been shown to produce intense metabolomics changes. The changes observed are in accordance with pharmacological data.