Quantitative proteomic changes during post myocardial infarction remodeling reveals altered cardiac metabolism and Desmin aggregation in the infarct region

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• 作者：Kaberi Datta^a ; Trayambak Basak^b ; ^c ; Swati Varshney^b ; ^c ; Shantanu Sengupta^b ; ^c ; Sagartirtha Sarkar^a ; ^{sagartirtha.sarkar@gmail.com}
• 关键词：Post myocardial infarction ; Remodeling ; Desmin ; Aggregate ; Proteomics ; iTRAQ
• 刊名：Journal of Proteomics
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：152
• 期：Complete
• 页码：283-299
• 全文大小：1854 K
• 卷排序：152

文摘

Proteome of infarct and non infarct zones compared as functions of differential oxidative stress during post MI remodeling. 285 proteins were present in at least 2 of 3 biological replicates with 111 proteins showing altered expression. 9 functional categories were involved with myocardial metabolism being the chief cellular process regulated. Cellular cytoskeletal architecture was remodeled due to aggregate formation by Desmin.