Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics

详细信息    查看全文

• 作者：Patrycja Puchalska¹ ; Peter A. Crawford¹ ; ² ; ^{pcrawford@sbpdiscovery.org}
• 关键词：fuel metabolism ; mitochondrial function ; HMGCS2 ; SCOT ; extrahepatic ketogenesis ; cancer metabolism ; NAFLD ; cardiac metabolism ; carbohydrate restriction ; ketogenic diet ; alternative fuel
• 刊名：Cell Metabolism
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：25
• 期：2
• 页码：262-284
• 全文大小：2269 K
• 卷排序：25

文摘

Ketone body metabolism is a central node in physiological homeostasis. In this review, we discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and organism performance in varying nutrient states and protect from inflammation and injury in multiple organ systems. Traditionally viewed as metabolic substrates enlisted only in carbohydrate restriction, observations underscore the importance of ketone bodies as vital metabolic and signaling mediators when carbohydrates are abundant. Complementing a repertoire of known therapeutic options for diseases of the nervous system, prospective roles for ketone bodies in cancer have arisen, as have intriguing protective roles in heart and liver, opening therapeutic options in obesity-related and cardiovascular disease. Controversies in ketone metabolism and signaling are discussed to reconcile classical dogma with contemporary observations.