Application of quantitative metabolomics in systems genetics in rodent models of complex phenotypes
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- 作者：Dominique Gauguiera ; b ; dominique.gauguier@crc.jussieu.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Functional genomics ; Genetic linkage ; Genetic association ; Genome ; Mouse ; Quantitative trait locus ; QTL ; Metabotypes ; Rat
- 刊名：Archives of Biochemistry and Biophysics
- 出版年：2016
- 出版时间：1 January 2016
- 年：2016
- 卷：589
- 期：Complete
- 页码：158-167
- 全文大小：2662 K
文摘
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Metabolomics is a powerful tool for molecular phenotyping in quantitative genetics.
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Methods for systematic quantitative trait locus mapping are applied to metabolomics.
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Metabolomics can be used to identify genetically determined disease biomarkers.
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Rodent genetic models allow multi-organs and biofluids metabolome profiling.
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Systems genetics enables integration of metabolomic with other -omic dimensions.