Reciprocal relationship between membrane type 1 matrix metalloproteinase and the algesic peptides of myelin basic protein contributes to chronic neuropathic pain
MT1-MMP generates the algesic MBP peptides in vitro and the damaged PNS. The algesic MBP induces MT1-MMP expression in the PNS. Short-term MT1-MMP blockade attenuates allodynia and the algesic MBP release.