Effect of glandular metastases on overall survival of patients with metastatic clear cell renal cell carcinoma in the antiangiogenic therapy era
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- 作者：Gwenaelle Gravis ; M.D.a ; gravisg@ipc.unicancer.fr" class="auth_mail" title="E-mail the corresponding author ; brice.chanez@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Brice Chanez ; M.D.a ; Lisa Derosa ; M.D.b ; Benoit Beuselinck ; M.D.c ; Philippe Barthelemy ; M.D.d ; Brigitte Laguerre ; M.D.e ; Pierre-Emmanuel Brachet ; M.D.f ; Florence Joly ; M.D.f ; Bernard Escudier ; M.D.b ; David J. Harrison ; M.D.g ; Alexander Laird ; M.B.Ch.B. ; M.R.C.S.h ; Naveen Vasudev ; M.B.Ch.B. ; Ph.D. ; M.R.C.P. ; B.M.Sc.i ; Christy Ralph ; A.P.i ; James Larkin ; M.A. ; F.R.C.P. ; Ph.D.j ; Hazel Lote ; M.A. ; M.B.B.S. ; M.R.C.P.j ; Naji Salem ; M.D.k ; Jochen Walz ; M.D.l ; Jeanne Thomassin ; M.D.m ; Patrick Sfumato ; Ph.D.n ; Grant D. Stewart ; B.Sc. (Hons) ; F.R.C.S.Ed. (Urol) ; M.B.Ch.B. ; Ph.D.h ; Jean Marie Boher ; Ph.D.n ; On behalf of the Renal Cross Channel Group
- 关键词：Kidney cancer ; Clear cell renal carcinoma ; Prognosis factors ; Glandular metastases ; Survival outcome ; Targeted therapies ; Antiangiogenic therapy
- 刊名：Urologic Oncology: Seminars and Original Investigations
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：34
- 期：4
- 页码：167.e17-167.e23
- 全文大小：415 K
文摘
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This retrospective multicenter study included metastatic renal cell carcinoma (mRCC).
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mRCC was treated with antiangiogenics and glandular metastasis (GM) was recorded.
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Metastases to the pancreas, adrenal gland, breast, thyroid, or parotid defined GM.
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Patients with GM as first metastatic presentation had longer overall survival.
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The GM localization was an independent prognostic factor for survival.