Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis

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• 作者：Jure Vajs^a ; Conor Proud^b ; Anamaria Brozovic^c ; Martin Gazvoda^a ; Adrian Lloyd^b ; David I. Roper^b ; Maja Osmak^c ; ^{Maja.Osmak@irb.hr} ; Janez Ko&scaron ; mrlj^a ; ^{janez.kosmrlj@fkkt.uni-lj.si} ; Christopher G. Dowson^b ; ^{C.G.Dowson@warwick.ac.uk}
• 关键词：Antibacterial agent ; Methicillin resistant Staphylococcus aureus (MRSA) ; Mycobacterium smegmatis ; Antibiotic resistance ; Triazene
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：127
• 期：Complete
• 页码：223-234
• 全文大小：1111 K
• 卷排序：127

文摘

New triazenes with antimicrobial properties are synthesized. High activity against MRSA (0.02 μg/mL) and M. Smegmatis (0.03 μg/mL) is shown. Compounds are not acting as growth inhibitors of mammalian cell lines or yeast. Selected triazene is subject to very low frequencies of resistance at <10−9. Whole genome sequencing of resistant isolates is performed.