Surveillance of tedizolid activity and resistance: In vitro susceptibility of Gram-positive pathogens collected over 5 years from the United States and Europe

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• 作者：Mekki Bensaci^a ; ^{Mekki.Bensaci@merck.com} ; Daniel Sahm^b
• 关键词：ABSSSI ; Acute bacterial skin and skin structure infections ; BHS ; β-hemolytic streptococci ; cfr ; Chloramphenicol-florfenicol resistance gene ; CLSI ; Clinical Laboratory and Standards Institute ; CoNS ; Coagulase-negative streptococci ; EUCAST ; European Committee on Antimicrobial Susceptibility Testing ; IHMA ; International Health Management Associates ; MIC ; Minimum inhibitory concentration ; MRSA ; Methicillin resistant Staphylococcus aureus ; MSSA ; Methicillin-susceptible Staphylococcus aureus ; optrA ; O
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：87
• 期：2
• 页码：133-138
• 全文大小：228 K
• 卷排序：87

文摘

Gram-positive clinical isolates (n = 11,231) from 2009 to 2013 were studied. Tedizolid inhibited 99.7% of all isolates at MIC ≤0.5 mg/L. Tedizolid activity was high in S. aureus irrespective of methicillin resistance. Tedizolid was equally potent regardless of vancomycin resistance in enterococci. Tedizolid was ≥4-fold more potent than linezolid against all groups.