Distinct effects of ketamine and acetyl l-carnitine on the dopamine system in zebrafish
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- 作者：Bonnie L. Robinson ; Melanie Dumas ; Elvis Cuevas ; Qiang Gu ; Merle G. Paule ; Syed F. Ali ; Jyotshna Kanungo ; jyotshnabala.kanungo@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：COMT ; catechol-O-methyl transferase ; DA ; dopamine ; DOPAC ; 3 ; 4-dihydroxyphenylacetic acid ; HVA ; homovanillic acid ; MAO ; monoamine oxidase ; 3-MT ; 3-methoxytyramine
- 刊名：Neurotoxicology and Teratology
- 出版年：2016
- 出版时间：March-April 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：52-60
- 全文大小：865 K
文摘
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Low doses of ketamine do not alter DA system in zebrafish embryos.
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Anesthetic dose of ketamine and ALCAR reduces DA levels and TH gene expression.
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ALCAR but not ketamine accelerates DA metabolism but does not alter MAO and COMT gene expression.
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Ketamine attenuates MAO gene expression at both sub-anesthetic and anesthetic doses.
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Low doses of ketamine as fast-acting anti-depressants may rely on the ability in suppressing the DA metabolizing enzyme, MAO.