Vitamin D signaling and the differentiation of developing dopamine systems
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- 作者：Renata A.N. Pertilea ; &dagger ; ; Xiaoying Cuia ; &dagger ; ; Darryl W. Eylesa ; b ; eyles@uq.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：3-MT ; 3-methoxytyramine ; ANOVA ; analysis of variance ; COMT ; catechol-o-methyl transferase ; DA ; dopamine ; DE ; deoxypinephrine ; DOPAC ; 3 ; 4-dihydroxyphenylacetic acid ; DVD ; vitamin D-deficient ; HPLC ; high pressure liquid chromatography ; HVA ; homovanillic acid ; NA ; noradrenaline ; RA ; retinoic acid ; RXRs ; retinoid X receptors ; TH ; tyrosine hydroxylase ; TR ; thyroid hormone receptor ; VDR ; vitamin D receptor
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：333
- 期：Complete
- 页码：193-203
- 全文大小：459 K
文摘
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Over-expression of the VDR in a neural cell line promotes dopamine neuron differentiation.
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1,25(OH)2D3 further enhances VDR’s differentiation of dopamine neurons.
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1,25(OH)2D3 upregulates COMT expression as well as its direct product the DA metabolite 3-MT.
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1,25(OH)2D3 enhances VDR binding to the COMT promoter strongly suggesting direct regulation.