Increased susceptibility of G-protein coupled receptor 6 deficient mice to MPTP neurotoxicity
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- 作者：Patrick Oeckl&dagger ; ; Boris Ferger ; boris.ferger@boehringer-ingelheim.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：3-MT ; 3-methoxytyramine ; AAALAC ; Association for Assessment and Accreditation of Laboratory Animal Care International ; aCSF ; artificial cerebrospinal fluid ; cAMP ; cyclic adenosine-3&prime ; 5&prime ; -monophosphate ; DA ; dopamine ; DOPAC ; 3 ; 4-dihydroxyphenylacetic acid ; GPCR ; G-protein coupled receptor ; GPR6 ; G-protein coupled receptor 6 ; HPLC ; High-performance liquid chromatography ; HVA ; 4-hydroxy-3-methoxyphenylacetic acid ; LC&ndash ; MS/MS ; liquid chromatography/tandem mass spectrometry ; MPP+ ; 1-met
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：19 November 2016
- 年：2016
- 卷：337
- 期：Complete
- 页码：218-223
- 全文大小：818 K
文摘
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GPR6 deficiency increases striatal tissue concentration of dopamine in mice.
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MPTP toxicity (i.e. striatal dopamine depletion, degeneration of nigral TH-positive neurons) is increased in GPR6−/−-mice.
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GPR 6 deficiency in mice increases MPP+-induced dopamine release in the striatum.