Agmatine induces apoptosis in rat hepatocyte cultures

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• 作者：Gardini ; Giulia ; Cabella ; Claudia ; Cravanzola ; Carlo ; Vargiu ; Cristina ; Belliardo ; Sabina ; et. al.
• 关键词：Agmatine ; Hepatocytes ; Apoptosis ; Caspase 3 ; AcDEVD-AL ; acetyl-Asp-Glu-Val-Asp-aldehyde ; AcDEVD-AMC ; acetyl-Asp-Glu-Val-Asp-amido-4-methylcoumarin ; CHAPS ; 3-[(3-cholamidopropyl) dimethylammonio]-1-propane-sulfonate ; CsA ; cyclosporin A ; MOPS ; 3-[N-morpholi
• 刊名：Journal of Hepatology
• 出版年：2001
• 出版时间：October, 2001
• 年：2001
• 卷：35
• 期：4
• 页码：482-489
• 全文大小：304 K

文摘

Background/Aims: Agmatine, the compound formed by decarboxylation of arginine, is believed to be an endogenous neurotransmitter through interaction with the imidazoline receptors. However, it also appears to regulate rat hepatocyte polyamines by modifying both their synthesis and their catabolism. As the decrease in polyamine content has been correlated with apoptosis, we examined the possibility that agmatine has an effect on this phenomenon.