Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine (‘ecstasy’)-induced serotonergic neurotoxicity
详细信息 查看全文
- 作者：I-Hsun Lia ; Kuo-Hsing Mab ; Tzu-Jen Kaoc ; d ; Yang-Yi Linb ; Shao-Ju Wengb ; Ting-Yin Yenb ; Lih-Chi Chene ; Yuahn-Sieh Huangb ; anatoman2001@yahoo.com.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：MDMA ; 3 ; 4-methylenedioxymethamphetamine ; LC3 ; microtubule-associated protein 1 light chain 3 ; SERT ; serotonin transporter ; TPH ; tryptophan hydroxylase ; SSRIs ; selective serotonin reuptake inhibitors ; 5-HT ; 5-hydroxytryptamine (serotonin) ; 3-MA ; 3-methyladenine ; PI3K ; phosphatidylinositol 3-kinase ; PE ; phosphatidylethanolamine ; ROS ; reactive oxygen species ; CNS ; central nervous system ; PET/SPECT ; positron emission computed tomography/single photo emission computed tomography ; VOIs ; volumes of int
- 刊名：Neurotoxicology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：52
- 期：Complete
- 页码：114-126
- 全文大小：2883 K
文摘
- •
Exposure to MDMA induces autophagy upregulation in cultured serotonergic neurons.
- •
Inhibition of autophagy by 3-MA protects serotonergic neurons against neurite degeneration and neuronal death.
- •
Serotonin transporter may mediated MDMA-induced neurotoxicity through modulating autophagy activity.
- •
Specific modulation of autophagy might be a novel neuroprotective strategy to attenuate MDMA-induced serotonergic neurotoxicity.