Differential effects of 3,4-methylenedioxymethamphetamine, methamphetamine, meta-Chlorophenylpiperazine, and scopolamine on behavioral repetition versus variation in rats

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• 作者：Rebecca A. Olsen ; Anne C. Macaskill ; ^{anne.macaskill@vuw.ac.nz} ; David N. Harper
• 关键词：MDMA ; Methamphetamine ; m-CPP ; Scopolamine ; Reinforced variability
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2016
• 出版时间：November-December 2016
• 年：2016
• 卷：150-151
• 期：Complete
• 页码：170-181
• 全文大小：830 K
• 卷排序：150

文摘

Drugs might cause variability, repetition, or impair stimulus control. Rats' lever pressing was reinforced on a Vary/Repeat multiple schedule. MDMA and METH primarily increased variability when repetition was required. M-CPP and scopolamine produced differential patterns of effect. The reinforced variability paradigm is sensitive to pharmacological manipulations.