New Generation Dopaminergic Agents. Part 8: Heterocyclic Bioisosteres that Exploit the 7-OH-2-(aminomethyl)chroman D₂ Template

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• 作者：Mewshaw ; Richard E. ; Zhao ; Rulin ; Shi ; Xiaojie ; Marquis ; Karen ; Brennan ; Julie A. ; Mazandarani ; Hossein ; et. al.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2002
• 出版时间：February 11, 2002
• 年：2002
• 卷：12
• 期：3
• 页码：271-274
• 全文大小：124 K

文摘

Based on the 7-OH-2-(aminomethyl)chroman dopamine D₂ template (2) is described the preparation and resolution of two bioisosteric analogues. The benzimidazol-2-one derivative (6) had similar affinity to the known indolone derivative (4).