Inside story of Group I Metabotropic Glutamate Receptors (mGluRs)
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- 作者：Samarjit Bhattacharyya samarjit@iisermohali.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endocytosis ; Trafficking ; Desensitization ; Receptor recycling ; GPCR ; Metabotropic glutamate receptors ; Neurotransmitter receptors
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：77
- 期：part_PB
- 页码：205-212
- 全文大小：1157 K
文摘
Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that are activated by the neurotransmitter glutamate in the central nervous system. Among the eight subtypes, mGluR1 and mGluR5 belong to the group I family. These receptors play important roles in the brain and are believed to be involved in multiple forms of experience dependent synaptic plasticity including learning and memory. In addition, group I mGluRs also have been implicated in various neuropsychiatric disorders like Fragile X syndrome, autism etc. The normal signaling depends on the precise location of these receptors in specific region of the neuron and the process of receptor trafficking plays a crucial role in controlling this localization. Intracellular trafficking could also regulate the desensitization, resensitization, down-regulation and intracellular signaling of these receptors. In this review I focus on the current understanding of group I mGluR regulation in the central nervous system and also their role in neuropsychiatric disorders.