Novel dinorcassane- and cassane-type diterpenes from the seeds of Caesalpinia minax

详细信息    查看全文

• 作者：Hai-Feng Wu^a ; Jing-Yi Hong^a ; Zhong-Hao Sun^a ; Jing-Quan Yuan^b ; Hua Wei^c ; Xiao-Po Zhang^a ; Yu Tian^a ; Ying-Di Zhu^a ; Jun-Shan Yang^a ; Guo-Xu Ma^a ; ^{mgxf18785@163.com" class="auth_mail} ; Xu-Dong Xu^a ; ^{xdxu@implad.ac.cn" class="auth_mail}
• 关键词：Caesalpinia minax ; Norcassane diterpene ; Cytotoxic activity ; Biosynthetic pathway
• 刊名：Fitoterapia
• 出版年：April, 2014
• 年：2014
• 卷：94
• 期：Complete
• 页码：172-176
• 全文大小：362 K

文摘

Two novel diterpenes, norcaesalpinin I (1) featuring an unusual ring C-contracted dinorcassane and caesalpinin U (2) possessing a highly oxygenated furanocassane skeleton were isolated from the seeds of Caesalpinia minax. Their structures were determined by different spectroscopic methods. A plausible biosynthetic pathway of 1 was proposed. The cytotoxic activity of compounds 1 and 2 against HepG2 and HeLa human tumor cell lines was evaluated.