Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)
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- 作者：Isolda Romero-Caneló ; na ; Ben Phoenixb ; Anaï ; s Pitto-Barrya ; Johanna Trana ; Joan J. Soldevila-Barredaa ; Nigel Kirbyc ; Stuart Greenb ; Stuart.Green@uhb.nhs.uk" class="auth_mail" title="E-mail the corresponding author ; Peter J. Sadlera ; P.J.Sadler@warwick.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Nicolas P.E. Barrya ; N.Barry@warwick.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Arene ruthenium ; Carborane ; Pluronic ; Micelles ; Boron neutron capture therapy
- 刊名：Journal of Organometallic Chemistry
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：796
- 期：Complete
- 页码：17-25
- 全文大小：1484 K
文摘
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Ruthenium carborane complexes can provide new BNCT agents.
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Formulation of those in micelles leads to increase in boron cell accumulation.
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Neutron irradiation has dramatic effect on antiproliferative activity.
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Versatile design strategy, with choice of the metal complex and polymer.