The chronic lymphocytic leukemia microenvironment: Beyond the B-cell receptor

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• 作者：Michael Y. Choi ; ^{mychoi@ucsd.edu" class="auth_mail" title="E-mail the corresponding author} ; Manoj Kumar Kashyap¹ ; ^{mkashyap@ucsd.edu" class="auth_mail" title="E-mail the corresponding author} ; Deepak Kumar¹ ; ^{dkumar@ucsd.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Chronic lymphocytic leukemia ; Microenvironment ; Stroma ; Nurse-like cell ; Mesenchymal stromal cell ; CXCR4 ; CXCL12 ; Chemokine ; Wnt
• 刊名：Best Practice Research Clinical Haematology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：29
• 期：1
• 页码：40-53
• 全文大小：706 K

文摘

Malignant B cells accumulate in the peripheral blood, bone marrow, and lymphoid organs of patients with chronic lymphocytic leukemia (CLL). In the tissue compartments, CLL shape a protective microenvironment by coopting normal elements. The efficacy of drugs that target these interactions further underscores their importance in the pathogenesis of CLL. While the B cell receptor (BCR) pathway clearly plays a central role in the CLL microenvironment, there is also rationale to evaluate agents that inhibit other aspects or modulate the immune cells in the microenvironment. Here we review the main cellular components, soluble factors, and signaling pathways of the CLL microenvironment, and highlight recent clinical advances. As the BCR pathway is reviewed elsewhere, we focus on other aspects of the microenvironment.