SUMO-Dependent Relocalization of Eroded Telomeres to Nuclear Pore Complexes Controls Telomere Recombination
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- 作者：Dmitri Churikov1 ; 3 ; Ferose Charifi1 ; 3 ; Nadine Eckert-Boulet2 ; Sonia Silva2 ; Marie-Noelle Simon1 ; marie-noelle.simon@inserm.fr" class="auth_mail" title="E-mail the corresponding author ; Michael Lisby2 ; mlisby@bio.ku.dk" class="auth_mail" title="E-mail the corresponding author ; Vincent Gé ; li1 ; vincent.geli@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：10 May 2016
- 年：2016
- 卷：15
- 期：6
- 页码：1242-1253
- 全文大小：3646 K
文摘
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SUMO modification accumulates at eroded telomeres after loss of telomerase
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SUMOlyation promotes recruitment of Slx5-Slx8 STUbL to eroded telomeres
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Rfa1 is SUMOylated during telomere erosion and physically interacts with Slx5
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STUbL-dependent targeting of telomeres to NPCs promotes type II recombination