Regulation of homologous recombination at telomeres in budding yeast

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• 作者：Nadine Eckert-Boulet ; Michael Lisby
• 关键词：Homologous recombination (HR) ; Recombinational telomere elongation (RTE) ; Replicative senescence ; Rad52 ; Replication protein A ; Cdc13
• 刊名：FEBS Letters
• 出版年：2010
• 出版时间：10 September 2010
• 年：2010
• 卷：584
• 期：17
• 页码：3696-3702
• 全文大小：447 K

文摘

Homologous recombination is suppressed at normal length telomere sequences. In contrast, telomere recombination is allowed when telomeres erode in the absence of telomerase activity or as a consequence of nucleolytic degradation or incomplete replication. Here, we review the mechanisms that contribute to regulating mitotic homologous recombination at telomeres and the role of these mechanisms in signalling short telomeres in the budding yeast Saccharomyces cerevisiae.