A novel pharmacokinetic model based on the complex elimination of monoclonal antibodies for bevacizumab pharmacokinetic study in rabbits
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- 作者：Lei Wang ; Shan Ji ; Meizhen Li ; Zeneng Cheng ; chengzn@csu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ADCC ; antibody dependent cellular cytotoxicity ; AUC ; area under the concentration&ndash ; time curve ; CL ; clearance ; mAbs ; monoclonal antibodies ; M&ndash ; M ; Michaelis&ndash ; Menten ; PBS ; phosphate-buffered saline ; PK ; pharmacokinetic ; TMB ; tetramethylbenzidine ; TMDD ; target-mediated drug disposition ; T1/2 ; half life ; V ; apparent volume of distribution ; VEGF ; vascular endothelial growth factor
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：39-44
- 全文大小：497 K
文摘
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A novel PK model was built to explain the complex elimination of bevacizumab.
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New model reasonably described the single PK profiles of bevacizumab in rabbits.
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This novel PK model contributes to the rational use of mAbs.