Gender-related differences of diabetic patients undergoing percutaneous coronary intervention with drug-eluting stents: A real-life multicenter experience

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• 作者：Paolo Buja ; Gianpiero D'Amico ; Michela Facchin ; Alberto Barioli ; Massimo Napodano ; Davide Capodanno ; Giuseppe Musumeci ; Anna Chiara Frigo ; Francesco Saia ; Alberto Menozzi ; Mauro De Benedictis ; Michael S. Lee ; Corrado Lettieri ; Corrado Tamburino ; Gennaro Sardella ; Giambattista Isabella ; Giuseppe Tarantini
• 关键词：Diabetes mellitus ; Drug-eluting stents ; Gender ; Outcome
• 刊名：International Journal of Cardiology
• 出版年：2013
• 出版时间：20 September, 2013
• 年：2013
• 卷：168
• 期：1
• 页码：139-143
• 全文大小：426 K

文摘

Background

Gender-based differences in diabetic patients are understudied in the field of percutaneous coronary intervention (PCI) with drug-eluting stents.

Methods

Data were obtained from a multicenter registry of 2420 consecutive patients with diabetes mellitus (DM) who underwent PCI with paclitaxel- or sirolimus-eluting stents between 2003 and 2009. Among them, 679 (28.1 % ) women were compared to 1741 (71.9 % ) men in terms of clinical aspects and major adverse cardiac events (MACE), including all-cause death, myocardial infarction (MI) and target lesion revascularization (TLR). Target vessel revascularization (TVR) and any revascularization were also reported.

Results

Women were less numerous, older, used more insulin and showed more tortuous coronary arteries, while men were more frequently smokers and received larger stents. At the median follow-up of 24.3 months (interquartile range 12.3-39.7), MACE, TVR and any revascularization did not significantly differ between females and males (19.9 % vs 18.7 % , 12.2 % vs 13.4 % , 14.1 % vs 15.1 % , respectively). At multivariable analysis of the overall cohort, female gender was not a predictor of MACE (hazard ratio [HR] 1.02, 95 % confidence interval [CI] 0.92-2.36, p = 0.11), death (HR 1.04, 95 % CI 0.84-1.24, p = 0.86), MI (HR 1.48, 95 % CI 0.92-2.36, p = 0.11), and TLR (HR 1.14, 95 % CI 0.85-1.52, p = 0.38).

Conclusion

In this registry of diabetic patients treated by drug-eluting stents, women were less represented, older and needed more insulin compared to men who, on the other hand, received larger stents. Gender-related outcomes were similar and female sex did not predict MACE.