Oxidative stress biomarkers in patients with untreated obstructive sleep apnea syndrome

详细信息    查看全文

• 作者：Michelangelo Mancuso ; ^{mancusomichelangelo@gmail.com} ; Enrica Bonanni ; Annalisa LoGerfo ; Daniele Orsucci ; Michelangelo Maestri ; Lucia Chico ; Elisa DiCoscio ; Monica Fabbrini ; Gabriele Siciliano ; Luigi Murri
• 关键词：AOPP ; Biomarkers ; FRAP ; Glutathione ; Obstructive sleep apnea syndrome ; OSA ; Oxidative stress ; ROS
• 刊名：Sleep Medicine
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：13
• 期：6
• 页码：632-636
• 全文大小：301 K

文摘

Background

The pathogenic role of oxidative stress in obstructive sleep apnea syndrome (OSAS) is still a matter of debate, with different studies obtaining contrasting results.

Methods

The aim of the present study was to evaluate three well-known markers of oxidative stress (advanced oxidation protein products [AOPP], ferric reducing antioxidant power [FRAP], and total glutathione [GSH]) in a cohort of 41 untreated patients with a new diagnosis of OSAS.

Results

We observed that OSAS patients showed increased protein oxidative damage and impaired antioxidant defenses. Patients with more severe OSAS had a lower total antioxidant capability. Preliminary data on a subgroup of patients (n = 7) treated with CPAP show a significant increment of the FRAP values (P < 0.005).

Conclusions

Our findings indicate that such oxidative stress markers may be useful to detect and monitor redox imbalance in OSAS. Moreover, FRAP might be a new useful biomarker to monitor in vivo the oxidative response to CPAP therapy.