Interferon-α or β potentiate platinum analogous in human glioblastoma cell lines
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- 作者：Stanzione ; Sabrina ; Cimoli ; Guido ; Debernardis ; Domizia ; Michelotti ; Andrea ; Conte ; PierFranco ; et. al.
- 关键词：Interferons ; Platinum ; DNA damage ; Potentiation ; Glioman
- 刊名：Mutation Research Letters
- 出版年：1995
- 出版时间：November, 1995
- 年：1995
- 卷：348
- 期：3
- 页码：131-135
- 全文大小：309 K
文摘
The effect of interferon-α or β on platinum analogues [cisplatin (CDDP) and carboplatin] cytotoxicity was studied in four glioblastoma cell lines (U373MG, T98G, A172 and U118Mg). All cell lines were strongly resistant to the cytotoxic effect of CDDP or carboplatin. Although both interferons were not cytotoxic in all cell lines, they were able to significantly increase the cell platinum-sensitivity. Specifically interferon-α increased the magnitude of CDDP-induced DNA interstrand crosslinks