Pre-transplant Quality of Life Does Not Predict Survival After Lung Transplantation
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- 作者：Karin M. Vermeulen ; Elisabeth M. TenVergert ; Erik A.M. Verschuuren ; Michiel E. Erasmus ; Wim van der Bij
- 关键词：GDNF ; RET ; GFR
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- 刊名：The Journal of Heart and Lung Transplantation
- 出版年：2008
- 出版时间：June 2008
- 年：2008
- 卷：27
- 期：6
- 页码：623-627
- 全文大小：90 K
文摘
The aim of the present work was to perform, by in situ hybridization, a time-course analysis of the glial cell line-derived neurotrophic factor (GDNF) and its receptor mRNA expression in two models of brain injury in the rat: (a) excitotoxic lesion by ibotenic acid injection in the hippocampal formation; (b) mechanical lesion by needle insertion through the cerebral cortex including the white matter of the corpus callosum. The time-course analysis, ranging from 6 h to 8 days, showed that the GDNF and its receptor (RET, GFR![]()
-1 and GFR![]()
-2) mRNA expressions were differentially up-regulated in both models of lesion. This in vivo regulation of the GDNF and its receptor mRNA expression indicates their involvement in the process of neuronal protection and regeneration occurring after brain injury.