Subjects were 234 boys and 203 girls, aged 3-6?years, in a cross-sectional study in Japan in 2006. Information related to children's sleep disturbance, sleep time, and behavioral problems was obtained from parent-administered questionnaires. Children's behavioral problems were assessed by the Strengths and Difficulties Questionnaire. The 6-sulfatoxymelatonin levels in first-void morning urine were measured by radioimmunoassay.
After multiple adjustments for covariates, children who often snore at night (P?= .011), awake at night (P?= .019), and looked tired in the daytime (P?= .041) had a higher total difficulties score. Earlier time of waking (trend P?= .021) and earlier time for bed (trend P?= .014) were associated with a lower total difficulties score. Children with higher creatinine-corrected 6-sulfatoxymelatonin had lower total difficulties scores (trend P?= .011). There were no associations between creatinine-corrected 6-sulfatoxymelatonin and sleep-related factors.
Sleep disturbance, later times of sleeping and waking up, and lower melatonin levels might be involved in the development of pediatric behavioral disorders.