Temporal course of gene expression during motor memory formation in primary motor cortex of rats

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• 作者：B. Hertler^a ; M.M. Buitrago^a ; ^b ; A.R. Luft^a ; ^c ; ^d ; ^{andreas.luft@uzh.ch} ; J.A. Hosp^a ; ^e
• 关键词：Motor skill learning ; Motor cortex ; cDNA microarray ; Gene expression ; Neuronal plasticity ; Rat
• 刊名：Neurobiology of Learning and Memory
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：136
• 期：Complete
• 页码：105-115
• 全文大小：2974 K
• 卷排序：136

文摘

Motor learning induces a sequential gene regulation with high time-point specificity. A shift from initial suppression is followed by a predominant up-regulation. The majority of regulated genes can be linked to learning-related plasticity. The temporal profile of gene regulation is slower when compared to hippocampus-dependent learning.