Longer-term impact of hemiparetic stroke on skeletal muscle metabolism—A pilot study

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• 作者：Jennifer Klaer^a ; Anja Mä ; hler^b ; Nadja Scherbakov^a ; Lars Klug^b ; Stephan von Haehling^c ; Michael Boschmann^b ; ¹ ; Wolfram Doehner^a ; ^d ; ¹ ; ^{wolfram.doehner@charite.de}
• 关键词：Stroke ; Energy metabolism ; Calorimetry ; Microdialysis ; Mitochondrial function ; Muscle tissue perfusion
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：230
• 期：Complete
• 页码：241-247
• 全文大小：684 K
• 卷排序：230

文摘

Hemiparetic stroke leads to structural and metabolic alterations of skeletal muscle tissue, thereby contributing to functional impairment associated with stroke. In situ metabolic processes at tissue level in skeletal muscle have not been investigated. We hypothesize that muscular metabolic capacity is limited after hemiparetic stroke, and that changes affect rather the paretic than non-paretic limb.MethodsNine male hemiparetic stroke survivors (age, 62 ± 8 years; BMI, 28 ± 4 kg/m2; median stroke latency, 23 months ranging from 7 to 34 months poststroke) underwent dynamic in situ measurements of carbohydrate and lipid metabolism at fasting condition and during oral glucose tolerance testing, using bilateral microdialysis. Results were compared to 8 healthy male subjects of similar age and BMI.ResultsTissue perfusion, fasting and postprandial profiles of interstitial metabolites glucose, pyruvate, lactate and glycerol did not differ between paretic and non-paretic muscle. Patients displayed higher fasting and postprandial dialysate glycerol levels compared to controls (P < 0.001) with elevated plasma FFA (fasting FFA; 0.63 ± 0.23 vs. 0.29 ± 0.17 mmol/L; P = 0.004). Glycolytic activity was higher in patients vs. controls, with increased lactate production upon glucose load (P < 0.001).ConclusionsAn elevated lipolytic and glycolytic activity on tissue level suggests an impaired substrate metabolism with blunted oxidative metabolism in bilateral skeletal muscle in patients after hemiparetic stroke. Muscular metabolic properties did not differ between paretic and non-paretic leg. Further work is needed to investigate the clinical impact of this impaired muscular metabolic capacity in post-stroke patients.