Sulforaphane induces Nrf2 target genes and attenuates inflammatory gene expression in microglia from brain of young adult and aged mice
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- 作者：Brigitte E. Townsenda ; Rodney W. Johnsona ; b ; rwjohn@illinois.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARE ; antioxidant response element ; GCLM ; glutamate&ndash ; cysteine ligand modifier subunit ; HMOX1 ; heme oxygenase I ; IL ; interleukin ; iNOS ; inducible nitric oxide synthase ; LPS ; lipopolysaccharide ; NQO1 ; NAD(P)H quinone oxidoreductase ; Nrf2 ; nuclear factor erythroid 2-related factor ; qPCR ; real-time quantitative RT-PCR ; SFN ; sulforaphane
- 刊名：Experimental Gerontology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：73
- 期：Complete
- 页码：42-48
- 全文大小：647 K
文摘
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Sulforaphane (SFN) activated Nrf2 in BV2 cells and increased antioxidant genes.
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SFN reduced proinflammatory cytokines in LPS-stimulated BV2 microglia.
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SFN increased expression of antioxidant genes in adult and aged microglia.
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SFN reduced LPS-induced proinflammatory cytokines in adult and aged microglia.
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SFN is a potential therapeutic supplement for aging-related neuroinflammation.