Alpha-synuclein activates BV2 microglia dependent on its aggregation state
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- 作者：Alana Hoffmanna ; 2 ; Benjamin Ettlea ; 2 ; Ariane Brunoa ; Anna Kulinichb ; Anna-Carin Hoffmannc ; Julia von Wittgensteina ; c ; Jü ; rgen Winklera ; Wei Xiangc ; 3 ; Johannes C.M. Schlachetzkia ; 1 ; 3 ; jschlachetzki@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alpha-synuclein ; Fibrils ; Microglia ; Inflammation ; Synucleinopathies
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：28 October 2016
- 年：2016
- 卷：479
- 期：4
- 页码：881-886
- 全文大小：1264 K
文摘
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Physico-chemical modification of alpha-synuclein leads to oligomerization and fibrillization.
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Primarily fibrillar alpha-synuclein increased production and secretion of TNF-α and IL-1β in BV2 cells.
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Fibrillar alpha-synuclein was efficiently internalized by BV2 cells.
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Exposure to alpha-synuclein had no detrimental effects on viability of BV2 cells.