Automotive airborne brake wear debris nanoparticles and cytokinesis-block micronucleus assay in peripheral blood lymphocytes: A pilot study
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- 作者：Alena Kazimirovaa ; alena.kazimirova@szu.sk" class="auth_mail" title="E-mail the corresponding author ; Pavlina Peikertovab ; c ; Magdalena Barancokovaa ; Marta Staruchovaa ; Jana Tulinskaa ; Miroslav Vaculikb ; Ivo Vavrab ; d ; Jana Kukutschovab ; Peter Filipe ; Maria Dusinskaf
- 关键词：Brake wear debris nanoparticles ; Genotoxicity ; Cytokinesis-block micronucleus assay ; Blood lymphocytes
- 刊名：Environmental Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：443-449
- 全文大小：860 K
文摘
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BWD was characterized by Raman microspectroscopy, scanning electron microscopy, and transmission electron microscopy.
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Our result showed that BWD contains crystalline metal NPs.
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Two different protocols for CBMN assay were used to study of genotoxicity of BWD.
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We found significantly increased frequency of MNBNCs after 48 h exposure of BWD (with 10% of foetal calf serum in culture media) at the concentration 3 µg/cm2.