Microtubule Motors Drive Hedgehog Signaling in Primary Cilia

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• 作者：Mu He¹ ; Stephanie Agbu² ; ³ ; Kathryn V. Anderson² ; ^{k-anderson@ski.mskcc.org}
• 关键词：primary cilia ; microtubules ; kinesin ; dynein ; ciliopathies ; Hedgehog pathway
• 刊名：Trends in Cell Biology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：27
• 期：2
• 页码：110-125
• 全文大小：3229 K
• 卷排序：27

文摘

The mammalian Hedgehog (Hh) signaling pathway is required for development and for maintenance of adult stem cells, and overactivation of the pathway can cause tumorigenesis. All responses to Hh family ligands in mammals require the primary cilium, an ancient microtubule-based organelle that extends from the cell surface. Genetic studies in mice and humans have defined specific functions for cilium-associated microtubule motor proteins: they act in the construction and disassembly of the primary cilium, they control ciliary length and stability, and some have direct roles in mammalian Hh signal transduction. These studies highlight how integrated genetic and cell biological studies can define the molecular mechanisms that underlie cilium-associated health and disease.