Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model
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- 作者：Ken-Ming Changa ; Huang-Hui Chenb ; c ; 1 ; Tai-Chi Wangd ; 1 ; I-Li Chend ; Yu-Tsen Chenb ; Shyh-Chyun Yanga ; e ; Yeh-Long Chenf ; Hsin-Huei Changb ; Chih-Hsiang Huangb ; Jang-Yang Changg ; h ; Chuan Shihb ; Ching-Chuan Kuob ; h ; i ; cckuo@nhri.org.tw" class="auth_mail" title="E-mail the corresponding author ; Cherng-Chyi Tzenga ; f ; tzengch@kmu.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nrf2/ARE activators ; Oxime-bearing coumarins ; Antioxidant activity ; Cytoprotection
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：106
- 期：Complete
- 页码：60-74
- 全文大小：1650 K
文摘
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Certain oxime-bearing coumarins were design and synthesized as Nrf2 activators.
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Compound 17a was able to activate Nrf2/ARE pathway in vivo.
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Compound 17a increased Nrf2 nuclear translocation.
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Compound 17a increased the expression of Nrf2-mediated cytoprotective proteins.
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Compound 17a significantly reduced t-BOOH-induced oxidative stress.