One-pot dichlorinative deamidation of primary β-ketoamides

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• 作者：Congke Zheng^a ; Xiaohui Zhang^a ; Muhammad Ijaz Hussain^a ; Mingming Huang^a ; Qing Liu^a ; Yan Xiong^a ; ^{xiong@cqu.edu.cn} ; Xiangming Zhu^b ; ^{xiangming.zhu@ucd.ie}
• 关键词：Dichlorinative deamidation ; α ; α-dichloroketones ; β-ketoamides ; Ketonic cleavage ; N-chlorosuccinimide
• 刊名：Tetrahedron Letters
• 出版年：2017
• 出版时间：8 February 2017
• 年：2017
• 卷：58
• 期：6
• 页码：574-577
• 全文大小：1587 K
• 卷排序：58

文摘

An approach for the dichlorinative deamidation of primary β-ketoamides is developed. Primary β-ketoamide gives rise to dichlorinated ketone through a ketonic cleavage. A mechanism involving tandem process of dichlorination and deamidation is proposed.