Expression Profiles of Inflammation-associated microRNAs in Periapical Lesions and Human Periodontal Ligament Fibroblasts Inflammation
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- 作者：Junli Yue ; DDS ; Dongzhe Song ; DDS ; Wanlu Lu ; DDS ; Ying Lu ; DDS ; PhD ; Wei Zhou ; DDS ; Xuelian Tan ; DDS ; Lan Zhang ; DDS ; PhD ; zlnancy914@sina.com" class="auth_mail" title="E-mail the corresponding author ; Dingming Huang ; DDS ; PhD ; dingminghuang@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apical periodontitis ; human periodontal ligament fibroblasts ; microRNA-155 ; proinflammatory cytokines ; Semaphorein3a
- 刊名：Journal of Endodontics
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：42
- 期：12
- 页码：1773-1778
- 全文大小：1178 K
文摘
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We provided expression profiles of inflammation-associated microRNAs (miRNAs) in apical periodontitis lesions and human periodontal ligament fibroblasts (HPDLFs) inflammation.
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We showed miR-155 induced proinflammatory phenotype in HPDLFs by a novel target gene SEMA3A.
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As a direct target of miR-155, SEMA3A could influence miR-155 in HPDLFs as well.
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Both miR-155 and SEMA3A had an impact on the other miRNAs (miR-29b, 106b, 125b, 143, and 198).