Piglets with maternally derived antibodies from sows immunized with rAdV-SFV-E2 were completely protected against lethal CSFV challenge
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- 作者：Shui-Li Xia1 ; Mingliang Du1 ; Jian-Lin Lei ; Yan Liu ; Yimin Wang ; Shengwei Ji ; Guang-Tao Xiang ; Lian-Feng Li ; Xin Cong ; Yuzi Luo ; Lina Shao ; Hua-Ji Qiu ; huajiqiu@hvri.ac.cn" class="auth_mail" title="E-mail the corresponding author ; qiuhuaji@163.com" class="auth_mail" title="E-mail the corresponding author ; Yuan Sun ; sunyuan@hvri.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Classical swine fever ; Marker vaccine ; Maternally derived antibodies ; Passive protection
- 刊名：Veterinary Microbiology
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：190
- 期：Complete
- 页码：38-42
- 全文大小：287 K
文摘
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rAdV-SFV-E2 is an adenovirus-delivered, alphavirus replicon-vectored vaccine against CSF.
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Maternally derived antibodies (MDAs) from rAdV-SFV-E2-immunized sows were evaluated for passive protection.
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MDAs were detected in piglets from the sow immunized with 4 × 106 TCID50 rAdV-SFV-E2.
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Piglets with MDAs from the immunized sow were fully protected from lethal CSFV challenge.
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Piglets with undetectable MDAs from the immunized sow were partially protected.