MicroRNA-136 inhibits cancer stem cell activity and enhances the anti-tumor effect of paclitaxel against chemoresistant ovarian cancer cells by targeting Notch3

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• 作者：Ju-Yeon Jeong^a ; ^b ; Haeyoun Kang^a ; ^b ; Tae Hoen Kim^a ; ^b ; Gwangil Kim^a ; ^b ; Jin-Hyung Heo^a ; Ah-Young Kwon^a ; Sewha Kim^a ; ^b ; Sang-geun Jung^c ; Hee-Jung An^a ; ^b ; ^{hjahn@cha.ac.kr}
• 关键词：Ovarian cancer ; miR-136 ; Notch3 signaling ; Chemoresistance ; Cancer stem cells
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：386
• 期：Complete
• 页码：168-178
• 全文大小：2111 K
• 卷排序：386

文摘

miR-136 functions as a tumor suppressor and directly targets Notch3 oncogene. Low miR-136 expression correlated with poor overall survival in ovarian cancer patients. Transfection of miR-136-mimic reduced cell growth and migration, and increased apoptosis of ovarian cancer cells.