miR-182 upregulation was correlated with decreased BDNF expression in the hippocampus of CUMS model.
an anti-depressant like effect was observed when LV-BDNF or LV-si-miR-182 was injected into the rats hippocampus.
miR-182 overexpression exacerbated depression-like behaviors.
BDNF and CREB1 were negatively regulated by miR-182.