miR-182 (microRNA-182) suppression in the hippocampus evokes antidepressant-like effects in rats
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- 作者：Yuefeng Lia ; b ; Siyue Lic ; Jinchuan Yana ; Dongqing Wanga ; Ruigen Yina ; Liang Zhaoa ; Yan Zhua ; Xiaolan Zhub ; d ; jiangdalyf2009@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：BDNF ; Depression ; Hippocampus ; miR-182
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：4 February 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：96-103
- 全文大小：868 K
文摘
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miR-182 upregulation was correlated with decreased BDNF expression in the hippocampus of CUMS model.
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an anti-depressant like effect was observed when LV-BDNF or LV-si-miR-182 was injected into the rats hippocampus.
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miR-182 overexpression exacerbated depression-like behaviors.
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BDNF and CREB1 were negatively regulated by miR-182.