Expression of procollagen α1 type I and tenascin proteins induced by HEMA in human pulp fibroblasts
详细信息 查看全文
- 作者：Michela Zago ; Gabriella Teti ; Giovanni Mazzotti ; Aless ; ra Ruggeri ; Lorenzo Breschi ; Susi Pelotti ; Michela Ortolani ; Mirella Falconi
- 关键词：Biocompatibility ; HEMA monomer ; Human pulp fibroblasts ; Tenascin ; Procollagen
; //www.sciencedirect.com/scidirimg/entities/204e.gif"" alt=""greek small letter alpha"" title=""greek small letter alpha"" border=""0"">1 type I
- 刊名：Toxicology in Vitro
- 出版年：2008
- 出版时间：August 2008
- 年：2008
- 卷：22
- 期：5
- 页码：1153-1159
- 全文大小：1598 K
文摘
In the dental pulp extracellular matrix, the main macromolecules are collagenous proteins, non-collagenous proteins and proteoglycans. Regulated synthesis of the interstitial collagens, in particular, type I collagen, is important during development and wound healing but also in a number of pathological conditions. Tenascin is also a matrix protein highly expressed during development while it decreases in mature organs. Under pathological conditions such as infections and inflammation, during tumorigenesis and mechanical stress applied to cells in culture or tissue in vivo, the expression of tenascin is increased.