Biocatalytic and chemocatalytic approaches to the highly stereoselective 1,2-reduction of an α,β-unsaturated ketone

详细信息    查看全文

• 作者：Birgit Kosjek ; David M. Tellers ; Mirlinda Biba ; Roger Farr ; Jeffrey C. Moore
• 刊名：Tetrahedron: Asymmetry
• 出版年：2006
• 出版时间：27 October 2006
• 年：2006
• 卷：17
• 期：19
• 页码：2798-2803
• 全文大小：152 K

文摘

Two methods are reported for synthesizing a chiral allylic alcohol from the corresponding racemic α,β-unsaturated ketone. Transition metal-based transfer hydrogenation provides the desired allylic alcohol in high enantiomeric purity but low diastereomeric excess. In contrast, an enzymatic dynamic kinetic reduction proceeds with high diastereoselectivity and enantioselectivity.