Greening analytical chromatography
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- 作者：Christopher J. Welch ; Naijun Wu ; Mirlinda Biba ; Robert Hartman ; Tanja Brkovic ; Xiaoyi Gong ; Roy Helmy ; Wes Schafer ; James Cuff ; Zainab Pirzada ; Lili Zhou
- 关键词：Acetonitrile ; Analytical separation ; Ethanol ; Fast chromatography ; Green analytical chemistry ; Microflow chromatography ; Solvent saving ; Supercritical-fluid chromatography ; Superheated water chromatography ; Waste
- 刊名：TrAC Trends in Analytical Chemistry
- 出版年：2010
- 出版时间：July-August 2010
- 年：2010
- 卷：29
- 期：7
- 页码：667-680
- 全文大小：1005 K
文摘
We review recent approaches for greening analytical separation technologies. Whereas conventional analytical separation technologies produce as much as 50 mL of waste per analysis, greener options considerably reduce the amount of waste generated per analysis, ranging from simply adoptable small-particle stationary-phase technologies and reduced column diameters to more specialized technologies [e.g., ultra-high-pressure liquid chromatography (UHPLC), supercritical-fluid chromatography (SFC) and microscale or nanoscale HPLC]. In addition, greener eluents and chromatography conditions can also be used, including substitution of ethanol for acetonitrile in reversed-phase HPLC and the use of water alone as an eluent at elevated temperatures. We describe the merits of these emerging technologies, and discuss the factors influencing the decision to move from conventional analytical separation methodologies to greener alternatives.