Cellular Allometry of Mitochondrial Functionality Establishes the Optimal Cell Size
详细信息 查看全文
- 作者：Teemu P. Miettinen1 ; 2 ; 3 ; Mikael Bjö ; rklund1 ; 4 ; mikael.bjorklund.lab@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：cell size ; growth ; mitochondria ; allometry ; mevalonate pathway ; mitochondrial dynamics ; organelle scaling ; Drp1 ; fitness ; metabolism
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：7 November 2016
- 年：2016
- 卷：39
- 期：3
- 页码：370-382
- 全文大小：4228 K
文摘
- •
Mitochondrial functionality is highest in intermediate-sized cells in a population
- •
Mitochondrial membrane potential changes with cell size, not cell cycle
- •
Evidence for an optimal cell size, whereby functionality and fitness are maximized
- •
Mitochondrial dynamics and mevalonate pathway required for the optimal cell size