Associations With Eicosapentaenoic Acid to Arachidonic Acid Ratio and Mortality in Hospitalized Heart Failure Patients

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• 作者：Shunsuke Watanabe ; MD¹ ; Akiomi Yoshihisa ; MD ; PhD¹ ; ² ; ^{yoshihis@fmu.ac.jp} ; Yuki Kanno ; MD¹ ; Mai Takiguchi ; MD¹ ; Tetsuro Yokokawa ; MD¹ ; Akihiko Sato ; MD¹ ; Shunsuke Miura ; MD¹ ; Takeshi Shimizu ; MD ; PhD¹ ; Satoshi Abe ; MD¹ ; Takamasa Sato ; MD ; PhD¹ ; Satoshi Suzuki ; MD ; PhD¹ ; ² ; Masayoshi Oikawa ; MD ; PhD¹ ; Nobuo Sakamoto ; MD ; PhD¹ ; Takayoshi Yamaki ; MD ; PhD¹ ; Koichi Sugimoto ; MD ; PhD¹ ; Hiroyuki Kunii ; MD ; PhD¹ ; Kazuhiko Nakazato ; MD ; PhD¹ ; Hitoshi Suzuki ; MD ; PhD¹ ; Shu-ichi Saitoh ; MD ; PhD¹ ; Yasuchika Takeishi ; MD ; PhD¹ ; ²
• 关键词：Heart failure ; n-3 polyunsaturated fatty acids ; eicosapentaenoic acid to docosahexaenoic acid ratio ; prognosis
• 刊名：Journal of Cardiac Failure
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：22
• 期：12
• 页码：962-969
• 全文大小：1011 K
• 卷排序：22

文摘

Although the ratio of eicosapentaenoic acid (EPA; n-3 PUFA) to arachidonic acid (AA; n-6 PUFA) has recently been recognized as a risk marker of cardiovascular disease, the prognostic impact of the EPA/AA ratio on patients with heart failure (HF) remains unclear. In this study, HF patients with a lower circulating EPA/AA ratio exhibited higher cardiac mortality than in HF patients with a higher EPA/AA ratio. The impact of EPA/AA ratio on cardiac mortality was more pronounced among patients taking statins than in those not taking statins.