Calcium signaling properties of a thyrotroph cell line, mouse TαT1 cells
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- 作者：Melanija Tomića ; Paula Bargi-Souzaa ; b ; Elias Leiva-Salcedoa ; 1 ; Maria Tereza Nunesb ; Stanko S. Stojilkovica ; stojilks@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATP ; Calcium influx ; Calcium mobilization ; P2Y receptors ; Thyrotrophs ; Thyrotropin-releasing hormone ; Triiodothryonine
- 刊名：Cell Calcium
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：58
- 期：6
- 页码：598-605
- 全文大小：1215 K
文摘
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TαT1 thyrotrophs are excitable and generate spontaneous action potentials.
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These cells express functional calcium-mobilizing TRH and P2Y1 receptors.
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Their activation triggers rapid Ca2+ mobilization coupled to sustained Ca2 influx.
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Both store-operated and voltage-gated calcium entry contribute to sustained calcium influx.
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Cellular calcium homeostasis is affected by triiodothyronine.